- Pramod Kaitheri Kandoth
- Ramalingaswami Fellow
- Joining Date in NABI: August 17, 2017
- 0172-5221126
- pramod@nabi.res.in
Discipline and Specialization:
Plant Molecular Biology and Biochemistry, Functional genomics, Genomics
Training/advance exposure in the area of work:
1. 1998-2004 Ph. D. Department of Biochemistry, Indian Institute of Science, Bangalore.
2. 2005-2007 Postdoctoral Fellow, Department of Biological Sciences, University of South Carolina, Columbia, SC, USA
3. 2007- 2012 Postdoctoral Fellow, Division of Plant Sciences, University of Missouri, Columbia, MO, USA
4. 2012-2017 Research Associate, Division of Plant Sciences, University of Missouri, Columbia, MO, USA
Current area of research:
Lathyrus (Lathyrus sativus) is a nutrient rich, drought tolerant legume of immense economic importance but has not been widely cultivated, because of the presence of neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid (β-ODAP) in the seeds that causes neurological disease, lathyrism. Genes and genetic factors determining ODAP production need to be understood to facilitate optimization of the strategies to develop low or no ODAP cultivars. Many genes in the biochemical pathway leading to the production of β-ODAP have not been cloned yet. Our strategy is to combine genetic, genomic and biochemical approaches to identify genes and their function leading to biotechnological applications including genome editing. These studies combined with plant breeding will help in developing low or no β-ODAP in the background of elite cultivars. Other interests include folate bio fortification in crop plants.
Publications (best five):
1. Kandoth, P.K., Liu, S., Prenger, E., Ludwig, A., Lakhssassi, N., Heinz, R., Zhou, Z., Howland,A., Joshua Gunther,J., Eidson, S., Dhroso, A., LaFayette, P., Tucker, D., Johnson, S., Anderson, J ., Alaswad, A., Cianzio, S R., Wayne A. Parrott,W. A., Korkin, D., Meksem, K., Mitchum, M. G. (2017). Systematic Mutagenesis of Serine Hydroxymethyltransferase Reveals an Essential Role in Nematode Resistance. Plant Physiol. 175: 1370-1380.
2. Liu,S., Kandoth, P. K., Lakhssassi, N., Kang, J., Colantonio, V., Heinz, R., Yeckel, G., Zhou, Z., Bekal, S., Dapprich, J., Rotter, B., Cianzio, S., Mitchum, M.G., Meksem, K. (2017). The soybean GmSNAP18 gene underlies two types of resistance to soybean cyst nematode. Nature Communications 8, 14822.
3. *Liu,S., *Kandoth, P.K., Warren, S.D., Yeckel, G., Heinz, R., Alden, J., Yang, C., Jamai, A., ElMellouki, T., Juvale, P.S., Hill, J., Baum, T.J., Cianzio, S., Whitham, S. A., Korkin, D., Mitchum, M.G., Meksem K. (2012). A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens. Nature 492: 256–260. (*equal contribution).
4. *Kandoth, P.K., *Ithal, N., Recknor, J., Maier, T., Nettleton, D., Baum, T.J., Mitchum, M.G. (2011). The soybean Rhg1 locus for resistance to the soybean cyst nematode Heterodera glycines regulates expression of a large number of stress- and defense-related genes in degenerating feeding cells. Plant Physiol. 155: 1960-75. (*equal contribution).
5. Kandoth, P.K., Ranf, S., Pancholi, S.S., Jayanty, S., Walla, M.D., Miller, W., Howe, G.A., Lincoln, D.E., and Stratmann, J.W. (2007). Tomato MAPKs LeMPK1, LeMPK2, and LeMPK3 function in the systemin-mediated defense response against herbivorous insects. Proc Natl Acad Sci USA 104:12205–12210.
