- Nitin Kumar Singhal, PhD
- Scientist C
- Joining Date in NABI: 02/03/2012
- 0172-5221243
- nitin[at]nabi.res.in
Discipline and Specialization:
Food Science & Technology, Food Nanobioscience
Training/advance exposure in the area of work:
Post Doc (May 2009- Jan 2012): Dept. of Chemistry, Nanobioscience lab, Seoul National University, Seoul, South korea.
Contribution to the scientific advancement :
1.A process has been developed for immobilization of the chimeric enzyme, Smt3-d-psicose 3-epimerase, and production of nearly zero calorie sugar, D-psicose, from agro-industrial residues.(Patent File No. 201611044752)
2. Guanosine diphosphate (GDP) a promising natural small-molecule inhibitor that targets Hepcidin-FPN complex has been identified as an additional supplement to iron ameliorate AI.
Current area of research:
1. Iron homeostasis, nutritional iron deficiency and common lifestyle diseases
2. Development of calorimetric nanobiosensor to detect food borne bacteria
3. Enzyme immobilization: Development of new type of nanoparticles to immobilize enzyme to make enzyme more robust and reusable
Publications (best five):
1. Angmo S, Tripathi N, Abbat S, Sharma S, Singh SS, Halder A, Yadav K, Shukla G, Sandhir R, Rishi V, Bharatam PV, Yadav H, Singhal NK*. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferrportin interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. doi: 10.1038/srep40097. (Impact factor (IF): 5.228).
2. Singh V, Rakshit K, Rathee S, Angmo S, Kaushal S, Garg P, Chung JH, Sandhir R, Sangwan RS, Singhal N*. Metallic/bimetallic magnetic nanoparticle functionalization for immobilization of α-amylase for enhanced reusability in bio-catalytic processes. Bioresour Technol. 2016 Aug;214:528-33. doi: 10.1016/j.biortech.2016.05.002. (Impact factor (IF): 4.917).
3. Singhal NK, Mitra A, Rajsekhar G, Shaikh MM, Kumar S, Guionneau P, Rao CP. Role of the orientation of -OH groups in the sensitivity and selectivity of the interaction of M(2+) with ribosyl- and galactosyl-imino-conjugates. Dalton Trans. 2009 Oct 21;(39):8432-42. doi: 10.1039/b903668g. (Impact factor (IF): 4.177).
4. Ahuja R, Singhal NK, Ramanujam B, Ravikumar M, Rao CP. Experimental and computational studies ofthe recognition of amino acids by galactosyl-imine and -amine derivatives: an attempt to understand the lectin-carbohydrate interactions. J. Org. Chem. 2007 Apr 27;72(9):3430-42. (Impact factor (IF): 4.785).
5. Singhal NK1, Ramanujam B, Mariappanadar V, Rao CP. Carbohydrate-based switch-on molecular sensor for Cu(II)in buffer absorption and fluorescence study ofthe selective recognition of Cu(II) ions by galactosyl derivatives in HEPES buffer Org Lett. 2006 Aug 3;8(16):3525-8. (Impact factor (IF): 6.732). Journal of cereal science. 60: 389-396.
Awards and Fellowships
1. GATE 2002 Chemistry
2. Best Paper Award from IIT Bombay
3. Best Poster Awards in Bioprocessing India Conference Organized by CIAB, Mohali 2016
4. Qualified the entrance exam for IIT Roorkee, 2000 with 4th all India rank
5. Brain Pool Post doctoral research fellowship (2009-2012)
